adipose tissue lipolysis physiology and medicine

Lipolysis defect in white adipose tissue and ... - Physiology- adipose tissue lipolysis physiology and medicine ,2018-12-12 · RESEARCH ARTICLE Lipolysis defect in white adipose tissue and rapid weight regain X Michal Kasher-Meron,1 Dou Y. Youn,2 Haihong Zong,2 and Jeffery E. Pessin1,2 1Department of Medicine, Albert Einstein College of Medicine, Bronx, New York; and 2Department of Pharmacology, Albert Einstein College of Medicine, Bronx, New YorkDissecting adipose tissue lipolysis: molecular regulation ...Lipolysis is the process by which triglycerides (TGs) are hydrolyzed to free fatty acids (FFAs) and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase (ATGL), hormone-sensitive lipase (HSL), and monoglyceride lipase. The activity in the lipolytic pathway is tightly regulated by hormonal and nutritional factors. Under conditions of negative energy …



A beta cell ATGL-lipolysis/adipose tissue axis controls ...

The results support the concept that fuel excess can drive obesity and diabetes via hyperinsulinaemia, and that an islet beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion.

Lipolysis in human adipose tissue during exercise ...

2019-10-29 · Subcutaneous adipose tissue lipolysis was studied in vivo by Fick's arteriovenous (a-v) principle using either calculated (microdialysis) or directly measured (catheterization) adipose tissue venou...

Autophagy in Adipose Tissue Physiology and …

2019-8-20 · A dipose tissue is vital for the body, and it is now recognized as an endocrine organ that secretes key adipokines and hormones to maintain metabolic homeostasis. There are three types of adipose tissues with distinct cellular origin: white adipose tissue (WAT), brown adipose tissue (BAT), and bright or beige adipose tissue.

Adipose Tissue - an overview | ScienceDirect Topics

to isolate ascs, adipose tissue derived from liposuction involves mincing of the adipose tissue sample, digestion with collagenase, and extensive washing of the tissue with phosphate-buffered saline followed by centrifugation to separate the stromal population in the bottom layer of the pellet from the adipocytes in the top layer as shown in fig. …

Dissecting adipose tissue lipolysis: molecular regulation ...

2020-2-4 · Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease Lipolysis is the process by which triglycerides (TGs) are hydrolyzed to free fatty acids (FFAs) and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase (ATGL), hormone-sensitive lipase (HSL), and monoglyceride lipase.

Adipose tissue lipolysis : Current Opinion in Clinical ...

2019-4-10 · Purpose of review Adipose tissue lipolysis is a critical pathway for the maintenance of energy homeostasis through the degradation of triglycerides and the release of fatty acids into the circulation. The understanding of the cellular factors regulating triglyceride hydrolysis and the metabolic function of lipases has considerably expanded in the last few years, revealing an …

Adipose tissue hyaluronan production improves systemic ...

Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis ... Lipolysis Medicine & Life Sciences 68%. glucose Physics ... HA is also implicated in normal physiology. Therefore, we generated a Hyaluronan Synthase 2 transgenic mouse line, driven by a tet-response element ...

Adipose Tissue: Physiology to Metabolic Dysfunction ...

Like the obesity epidemic, our understanding of adipocytes and adipose tissue is expanding. Just in the past decade, substantial advances have led to new insights into the contributions of adipose tissue to normal physiology and obesity-related complications, which places adipocyte biology at the epicenter of a global pandemic of metabolic diseases.

Lipolysis defect in white adipose tissue and rapid weight ...

Taken together, white adipose tissue of lean mice with OM shows increased sensitization to HFD compared with white adipose tissue with no OM, rendering it resistant to catecholamineinduced lipolysis. This relative lipolytic defect is tissue-autonomous and could play a role in the rapid weight regain observed after weight loss.

Adipose tissue lipolysis is increased during a repeated ...

2019-10-30 · ADIPOSE TISSUE LIPOLYSIS ISincreased during exercise. The major stimulus for the enhanced lipolysis seems to be circulating catecholamines in combination with a low insulin concentration. The increased lipolysis and nonesterified fatty acid (NEFA) mobilization result in an increased concentration of circulating NEFA, which

Physiology and Physiopathology of Adipose …

The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose …

[PDF] The physiology and pharmacology of adipose tissue ...

SummaryThe regulation of adipose tissue lipolysis occupies a key position in the metabolic concert of carbohydrates and lipids, and insulin plays the role of the conductor. Insulin favours the storage of fat in adipose tissue by 3 mechanisms: — 1. it inhibits lipolysis; — 2. increases the glucose uptake, lipogenesis and reësterification of free fatty acids; — 3. enhances the activity …

E-Selectin-Dependent Inflammation and Lipolysis in …

2021-8-11 · E-Selectin-Dependent Inflammation and Lipolysis in Adipose Tissue Exacerbate Steatosis-to-NASH Progression via S100A8/9. ...

Effect of exercise on lipolysis in adipose tissue

2018-6-3 · exist in the responsiveness of adipose tissue to cate-cholamine stimulation. Subcutaneous abdominal adipose tissue is more sensitive to β-adrenergic stimulation [68–71] and less sensitive to α 2-recep-tor stimulation [69,72] compared with adipocytes Figure 1. Regulation of adipose tissue lipolysis by major lipolytic pathways.

Catecholamine effects on lipolysis and blood ... - Physiology

1998-7-1 · sympathetic nervous system (SNS) activation stimulates lipid mobilization in adipose tissue, which is the most important tissue for triglyceride storage and mobilization. The modulatory effects of physiological catecholamines on fat cell function involve various adrenergic-receptor (AR) subtypes ().The coexistence of numerous ARs that increase (β 1-, β 2-, and β 3-ARs) or …

[PDF] Adipose tissue cellularity and lipolysis. Response ...

Exercise training increased the potential of adipose tissue cells to release free fatty acids in response to epinephrine stimulation, and lipolysis was positively correlated with cell size within both treatment groups. Male rats a 5 wk of age were subjected to 13 wk of intensive treadmill running to study the effect of exercise on adipose tissue cellularity and lipolysis.

The physiology and pharmacology of adipose tissue ...

2017-8-28 · Metabolic Unit, Department of Medicine, University of Zurich, Switzerland Received September 11, 1967 Summary. The regulation of adipose tissue lipolysis occupies a key position in the metabolic concert of car- bohydrates and lipids, and insulin plays the role of the conductor.

Butyrate stimulates adipose lipolysis and mitochondrial ...

2017-8-15 · Physiology Exp Physiol 102.2 (2017) pp 273–281 273 Research PaperResearchPaper Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation-associated β3-adrenergic receptor activation in high-fat diet-induced obese mice Yimin Jia 1,JianHong1,2, Huifang Li ,YunHu …

Adipocyte pseudohypoxia suppresses lipolysis and ...

Prolyl hydroxylase enzymes (PHDs) sense cellular oxygen upstream of hypoxia-inducible factor (HIF) signaling, leading to HIF degradation in normoxic conditions. In this study, we demonstrate that adipose PHD2 inhibition plays a key role in the suppression of adipocyte lipolysis. Adipose Phd2 gene ab …

Adipose tissue hyaluronan production improves systemic ...

Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis ... Lipolysis Medicine & Life Sciences 68%. glucose Physics ... HA is also implicated in normal physiology. Therefore, we generated a Hyaluronan Synthase 2 transgenic mouse line, driven by a tet-response element ...

Adipose Tissue: What Is It, Location, Function, …

Adipose tissue is a specialized type of connective tissue that arises from the differentiation of mesenchymal stem cells into adipocytes during fetal development. Mesenchymal stem cells are pluripotent cells that can transform …

Adipose Tissue: Physiology to Metabolic Dysfunction ...

Like the obesity epidemic, our understanding of adipocytes and adipose tissue is expanding. Just in the past decade, substantial advances have led to new insights into the contributions of adipose tissue to normal physiology and obesity-related complications, which places adipocyte biology at the epicenter of a global pandemic of metabolic diseases.

Adrenergic control of human adipose tissue lipolysis ...

Adrenergic control of human adipose tissue lipolysis. ULF SMITH. Department of Medicine II, Sahlgren ‘s Hospital, Goteborg, Sweden. Search for more papers by this author. ULF SMITH. Department of Medicine II, Sahlgren ‘s Hospital, Goteborg, Sweden.

Some changes in adrenalin lipolysis in adipose tissue in ...

Lipolysis was studied in adipose tissue of adrenalectomized and intact rats with hypertension (spontaneous or renal) and in normotensive rats of the corresponding control groups. The degree of lipolysis (in the presence or absence of adrenalin) was judged from the quantity of nonesterified fatty acids in the tissue and the liberation of glycerol into the incubation medium in vitro. The ...

The Molecular Brakes of Adipose Tissue Lipolysis

Adipose tissue lipolysis is tightly regulated by endocrine, paracrine, autocrine and autonomic nervous systems, which modulate the activity of lipases by determining their intracellular locations and interactions with regulatory factors.

The physiology and pharmacology of adipose tissue ...

2017-8-28 · Metabolic Unit, Department of Medicine, University of Zurich, Switzerland Received September 11, 1967 Summary. The regulation of adipose tissue lipolysis occupies a key position in the metabolic concert of car- bohydrates and lipids, and insulin plays the role of the conductor.