adipose tissue macrophages going off track during obesity due

Adipose tissue macrophages : going off track during ...- adipose tissue macrophages going off track during obesity due ,Adipose tissue macrophages : going off track during obesity: Published in: Diabetologia, 879 - 894. ISSN 0012-186X. Author: Boutens, Lily; Stienstra, Rinke: Date issued: 2016: Access: Open Access : Reference(s) Adipose tissue, Fat, Immune cells, Inflammation, Insulin resistance, Macrophages, Metabolism, Obesity, Review: Language: English: Type: Article: Abstract …Lactate Is a Key Mediator That Links Obesity to Insulin ...19/01/2022·During early phases of obesity, an increase of proinflammatory signaling in adipose tissue is likely an adaptive response to prevent further development of insulin resistance via its effect on adipose tissue expansion and remodeling. At the same time, the local lactate concentration is not reaching a critical level to provoke apoptosis and overt inflammation due …



Adipose tissue macrophages: going off track during obesity ...

Adipose tissue macrophages: going off track during obesity: Published in: Diabetologia, 59, 879 - 894. ISSN 0012-186X. Author: Boutens, L .; Stienstra, R. Date issued: 2016: Access: Open Access: Type: Article: Abstract: Inflammation originating from the adipose tissue is considered to be one of the main driving forces for the development of insulin resistance and type 2 diabetes …

Unique metabolic activation of adipose tissue macrophages ...

14/01/2018·Unique metabolic and inflammatory activation in ATMs during obesity. (a) PCA of various tissue macrophages, separated based on their transcriptome.n = 2 for macrophages from peritoneum, small intestine and adipose tissue; n = 1 for other macrophages.Data are derived from GEO accession no. GSE53986. Percentage of explained variance (expl. var.) is …

Biology and function of adipose tissue macrophages ...

20/02/2018·Adipose tissue macrophages: going off track during obesity. Boutens L, Stienstra R. Diabetologia, 59(5):879-894, 03 Mar 2016 Cited by: 145 articles | PMID: 26940592 | PMCID: PMC4826424. Review Free to read & use

Adipose tissue macrophages: going off track during obesity

Adipose tissue macrophages: going off track during obesity Lily Boutens1,2 & Rinke Stienstra1,2 Received: 9 September 2015/Accepted: 3 February 2016/Published online: 3 March 2016 # The Author(s) 2016. This article is published with open access at Springerlink Abstract Inflammation originating from the adipose tis-sue is considered to be one of the …

Adipose tissue macrophages induce hepatic neutrophil ...

During obesity, adipose tissue macrophages (ATM) accumulate in the vAT of mice and humans.10 11 In addition to their elevated numbers, ATM phenotype changes during obesity development. vAT from lean subjects typically contains more mannose receptor C-type 1 positive (MRC1 +) CD11c − macrophages frequently described as ‘alternatively activated’ anti …

The Role of Adipose Tissue in Elevate ... - Crimson Publishers

Boutens L, Stienstra R (2016) Adipose tissue macrophages: going off track during obesity. Diabetologia 59(5): 879-894. Kang YE, Kim JM, Joung KH, Lee JH, You BR, et al. (2016) The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic ...

Adipose tissue macrophages: going off track during obesity

03/03/2016·Whereas macrophages in lean mice and humans make up around 5% of the cells in adipose tissue, during obesity they constitute up to 50% of all adipose tissue cells . As well as increasing in number, adipose tissue macrophages (ATMs) change their localisation and inflammatory features during obesity. Contrary to the lean state, in which ATMs are …

The Role of Adipose Tissue in Elevate ESR Level in Obese ...

5. Boutens L, Stienstra R (2016) Adipose tissue macrophages: going off track during obesity. Diabetologia 59(5): 879-894. 6. Kang YE, Kim JM, Joung KH, Lee JH, You BR, et al. (2016) The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity

Macrophages as Key Players during Adipose Tissue ... - Thieme

14 Boutens L, Stienstra R. Adipose tissue macrophages: going off track during obesity. Diabetologia 2016; 59 (05) 879-894 Diabetologia 2016; 59 (05) 879-894 15 Mulder P, Morrison MC, Wielinga PY, van Duyvenvoorde W, Kooistra T, Kleemann R. Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis …

Adipose tissue microenvironments during aging: Effects on ...

This pathway is reduced during aging, in part due to changes within adipocytes, but also due to altered interactions in the aged tissue. B. Macrophages are found throughout the tissue, including lining sympathetic nerves. Macrophages drive inflammaging in adipose tissue, contributing to tissue dysfunction. Macrophages may also degrade catecholamines or take …

Adipose tissue macrophages: going off track during obesity

06/03/2016·Adipose tissue macrophages: going off track during obesity Diabetologia. 2016 May;59(5):879-94. doi: 10.1007/s00125-016-3904-9. Epub 2016 Mar 3. Authors Lily Boutens 1 2 , Rinke Stienstra 3 4 Affiliations 1 Department of Medicine, Radboud University Medical Center, Nijmegen, the Netherlands. 2 Nutrition, Metabolism and Genomics Group, Wageningen …

Ejection of damaged mitochondria and their removal by ...

Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity. Cell ... that could derive from the uptake of damaged extracellular mitochondria when they are not efficiently cleared by macrophages (e.g., due to low or defective phagocytosis and/or macrophage recruitment). EVs contain a very large number of other …

Decreased infiltration of adipose tissue macrophages and ...

01/09/2021·Obesity is a low-grade inflammatory condition, which is characterized by the infiltration of macrophages in adipose tissue [11,12]. There are two primary subtypes of adipose tissue macrophages (ATMs): the classically activated proinflammatory M1 type and the alternatively activated anti-inflammatory M2 type .

Adipose tissue macrophages: going off track during obesity

Adipose tissue macrophages: going off track during obesity. Boutens L; Stienstra R; Diabetologia. DOI: 10.1007/s00125-016-3904-9. 221 Citations. Citations of this article. 392 Readers. Mendeley users who have this article in their library. Add to library. View PDF. This artice is free to access. Abstract. Inflammation originating from the adipose tissue is …

adipose tissue macrophages going off track during obesity ...

The Composition and Metabolism in Vitro of Adipose Tissue ...- adipose tissue macrophages going off track during obesity in the body ,Per Björntorp, Adipose Tissue Morphology and Morbid Obesity, Surgical Clinics of North America, 10.1016/S0039-6109(16)41977-8, 59, 6, (977-983), (1979). Crossref Arthur D. Hartman, Dean W. Christ, Effect of cell size, age and …

Adipose tissue macrophages: going off track during obesity ...

Inflammation originating from the adipose tissue is considered to be one of the main driving forces for the development of insulin resistance and type 2 diabetes in obese individuals. Although a plethora of different immune cells shapes adipose tissue inflammation, this review is specifically focused on the contribution of macrophages that reside in adipose tissue in lean …

Adipose Tissue Macrophages: MR Tracking to Monitor Obesity ...

This study demonstrates that cellular imaging by using P904 ultrasmall superparamagnetic iron oxide–enhanced MR imaging allows detection, localization, and …

TIM4+ adipose tissue-resident macrophages: new modulators ...

19/08/2021·Adipose tissue macrophages (ATMs) have important roles in the regulation of inflammatory responses and insulin resistance in obesity. A new study reports that a subpopulation of ATMs, TIM4 ...

Macrophage Populations in Visceral Adipose Tissue from ...

Obesity is associated with inflammatory changes and accumulation and phenotype polarization of adipose tissue macrophages (ATMs). Obese pregnant women have alterations in adipose tissue composition, but a detailed description of macrophage population is not available. In this study, we characterized macrophage populations in visceral adipose tissue (VAT) from …

(PDF) Tissue Immune Cells Fuel Obesity-Associated ...

Herein we discuss functions of adaptive immune The frequency of Th1 cells in human visceral adipose tissue cell subsets in AT, liver and intestine during obesity and obesity- (VAT) and subcutaneous adipose tissue (SAT) depots of obese but associated cancers, with additional focus on the importance of non-T2D human subjects is 10–20-fold greater than that of Th2, …

Adipose tissue macrophages: going off track during obesity

Adipose tissue macrophages: going off track during obesity: Author(s): Boutens, L.; Stienstra, R. Publication year: 2016: Source: ... * Identification of transcriptional differences between ATMs from lean vs obese adipose tissue at several key points during the development of obesity and insulin resistance may reveal upstream triggers, regulatory factors and …

Adipose tissue macrophages: going off track during obesity ...

Inflammation originating from the adipose tissue is considered to be one of the main driving forces for the development of insulin resistance and type 2 diabetes in obese individuals. Although a plethora of different immune cells shapes adipose tissue inflammation, this review is specifically focused on the contribution of macrophages that reside in adipose tissue in lean …

Adipose tissue macrophages: going off track during obesity ...

Both conventional and tissue-specific functions of adipose tissue macrophages (ATMs) in lean and obese adipose tissue are discussed and linked with metabolic and inflammatory changes that occur during the development of obesity. Furthermore, we will address various circulating and adipose tissue-derived triggers that may be involved in shaping the ATM phenotype and …

Adipose tissue macrophages: going off track during obesity ...

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Ejection of damaged mitochondria and their removal by ...

Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity. Cell ... that could derive from the uptake of damaged extracellular mitochondria when they are not efficiently cleared by macrophages (e.g., due to low or defective phagocytosis and/or macrophage recruitment). EVs contain a very large number of other …

(PDF) Obesity-induced insulin resistance and macrophage ...

PDF | Insulin resistance has long been established as the key metabolic defect linking obesity with its related cardio‐metabolic diseases including type... | Find, read and cite all the research ...