adipose tissue resident immune cells

Adipose Tissue-Resident Immune Cells in Obesity and Type 2 ...- adipose tissue resident immune cells ,Adipose tissue-resident immune cells have been observed, and the potential contribution of these cells to metabolic dysfunction has been appreciated in recent years. This review focused on adipose tissue-resident immune cells that are dysregulated in the context of obesity and T2D. We comprehensively overviewed emerging knowledge regarding the phenotypic and …Adipose Tissue-Resident Immune Cells in Obesity and Type 2 ...Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes Jingli Lu, Jingli Lu, Junjie Zhao, Junjie Zhao, Haiyang Meng, Haiyang Meng, Xiaojian Zhang, Xiaojian Zhang; Affiliations Jingli Lu Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Jingli Lu Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou …



Inflammation: From Cellular Mechanisms to Immune Cell ...

01/03/2021·Adipose tissue inflammation is initiated and sustained over time by dysfunctional adipocytes that secrete inflammatory adipokines and by infiltration of bone marrow-derived immune cells that signal via production of cytokines and chemokines. Despite its low-grade nature, adipose tissue inflammation negatively impacts remote organ function, a …

Frontiers | Adipose Tissue-Resident Immune Cells in ...

Tissue-resident immune cells play critical roles in regulating tissue function and homeostasis. Obesity-associated visceral adipose tissue inflammation is attributed to the accumulation of M1 macrophages which produce inflammatory cytokines like TNF-α, IL-6, and expansion of effector T cells like Th1 cells, CD8 + cytotoxic T cells which produce interferon-γ to further add to the …

Immune and non-immune functions of adipose tissue ...

05/11/2021·Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence. Much of the work into understanding the role of immune cells in adipose tissue has been in the context of obesity.

Resident and migratory adipose immune cells control ...

26/11/2021·Myeloid cells are the most abundant adipose tissue-resident immune cells. Tissue-resident macrophages derive from the yolk sac and are the first immune cells to seed adipose tissue, where they ...

Ejection of damaged mitochondria and their ... - cell

The mitochondria of brown adipose tissue undergo a deep rearrangement to produce heat. Here, Rosina et al. report that adrenergically stressed adipocytes eject damaged components of mitochondria via extracellular vesicles. Adipose tissue-resident macrophages remove extracellular mitochondria, ensuring thermogenesis. Defective clearance of extracellular …

Adipose tissue-resident immune ce... preview & related ...

Adipose tissue-resident immune cells have been observed, and the potential contribution of these cells to metabolic dysfunction has been appreciated in recent years. This review focused on adipose tissue-resident immune cells that are dysregulated in the context of obesity and T2D. We comprehensively overviewed emerging knowledge regarding the phenotypic and …

Adipose tissue - Wikipedia

Adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes. In addition to adipocytes, adipose tissue contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular endothelial cells and a variety of immune cells such as adipose tissue macrophages.Adipose tissue is derived from preadipocytes.

Inflammation: From Cellular Mechanisms to Immune Cell ...

01/03/2021·Adipose tissue inflammation is initiated and sustained over time by dysfunctional adipocytes that secrete inflammatory adipokines and by infiltration of bone marrow-derived immune cells that signal via production of cytokines and chemokines. Despite its low-grade nature, adipose tissue inflammation negatively impacts remote organ function, a …

Adipose tissue-resident immune cells: key players in ...

12/07/2012·Adipose tissue (AT) plays a pivotal role in whole-body lipid and glucose homeostasis. AT exerts metabolic control through various immunological mechanisms that instigated a new research field termed immunometabolism. Here, we review AT-resident immune cells and their role as key players in immunometabolism. In lean subjects, AT …

[PDF] The role of adipose tissue immune cells in obesity ...

Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT inflammation was proposed as a central mechanism connecting obesity with its metabolic and vascular complications. Resident immune cells constitute the second largest AT cellular component after adipocytes and as such play important roles in the maintenance of AT …

Resident and migratory adipose immune cells control ...

26/11/2021·Myeloid cells are the most abundant adipose tissue-resident immune cells. Tissue-resident macrophages derive from the yolk sac and are the first immune cells to seed adipose tissue, where they ...

Modification of subcutaneous white adipose tissue ...

associated chronic inflammation links adipose tissue and the immune system. The fatty acid (FA) composition of cells resident in adipose tissue influences both the innate and the adap- tive immune system and inflammatory signalling in the tissue through a range of diverse mechanisms.9 One mechanism by which this occurs is metabolism of poly-unsaturated FAs …

Adipose tissue-resident immune ce... preview & related ...

Adipose tissue-resident immune cells have been observed, and the potential contribution of these cells to metabolic dysfunction has been appreciated in recent years. This review focused on adipose tissue-resident immune cells that are dysregulated in the context of obesity and T2D. We comprehensively overviewed emerging knowledge regarding the phenotypic and …

Adipose Tissue Immune Response: Novel Triggers and ...

21/03/2022·Adipose tissue inflammation mediates the association between excessive body fat accumulation and several chronic inflammatory diseases. A high prevalence of obesity-associated adipose tissue inflammation was observed not only in patients with cardiovascular ...

Adipose Tissue Immune Response: Novel Triggers and ...

21/03/2022·Adipose tissue inflammation mediates the association between excessive body fat accumulation and several chronic inflammatory diseases. A high prevalence of obesity-associated adipose tissue inflammation was observed not only in patients with cardiovascular ...

Adipose Tissue-Resident Immune Cells in Obesity and Type 2 ...

22/05/2019·Adipose tissue-resident immune cells, including T cells , B cells , macrophages , and dendritic cell (DC) subsets (8, 9), are dysregulated in the context of obesity and are associated with the development of a disturbed immune system and progression of the disease. Other unconventional lymphocyte subtypes that reside in adipose tissue also contribute to …

Adipose tissue inflammation and metabolic dysfunction in ...

30/07/2020·Adipose tissue inflammation is initiated and sustained over time by dysfunctional adipocytes that secrete inflammatory adipokines and by infiltration of bone marrow-derived immune cells that signal via production of cytokines and chemokines. Despite its low-grade nature, adipose tissue inflammation negatively impacts remote organ function, a …

Circulating sex steroids coregulate adipose tissue immune ...

01/11/2017·Resident immune cells are present within adipose tissue and undergo dynamic changes in both number and phenotype during states of both positive and negative energy balance with associated adipose tissue remodeling (31, 57, 62, 76, 84).

Tissular Tregs: a unique population of adipose-tissue ...

This review highlights the major innate and adaptive immune cell subsets contributing to adipose-tissue inflammation, the key role played by fat-resident T regs, and the potential of T reg-based therapies for treatment of the metabolic syndrome. 3 1. Introduction In recent years, regulatory T (T reg) cells have emerged as one of the most important guardians of the …

Adipose Tissue Immune Response: Novel Triggers and ...

21/03/2022·Adipose tissue inflammation mediates the association between excessive body fat accumulation and several chronic inflammatory diseases. A high prevalence of obesity-associated adipose tissue inflammation was observed not only in patients with cardiovascular ...

British Library EThOS: The role of adipose tissue immune ...

This investigation explores the immune cell composition and role of different adipose tissues both in steady state and during immune responses in mice. Firstly, a detailed analysis of the immune cell composition of peritoneal adipose tissues was performed. To investigate the function and migratory properties of these tissue-resident cells, cytokine and chemokine …

Circulating sex steroids coregulate adipose tissue immune ...

01/11/2017·Resident immune cells are present within adipose tissue and undergo dynamic changes in both number and phenotype during states of both positive and negative energy balance with associated adipose tissue remodeling (31, 57, 62, 76, 84).

Stromal cells maintain immune cell homeostasis in adipose ...

04/05/2019·Our findings, coupled with those of Mathis and colleagues , indicate that ASPC-derived IL-33 simultaneously promotes ILC2 and T reg responses in adipose tissue, further highlighting the conserved functions of these tissue-resident cells in the regulation of both innate and adaptive lymphocyte responses. Reciprocally, these immune cells control a vital …

A Unique Population: Adipose-Resident Regulatory T Cells

Adipose-resident Treg cells have been suggested to be critical regulators of immune and metabolic microenvironment in adipose tissue, as well as involved in pathogenesis of obesity-related metabolic disorders. This review surveys existing information on adipose-resident Treg cells. We first describe the origin, phenotype and function of adipose-resident Treg cells. We …

Regulation, Communication, and Functional Roles of Adipose ...

Evidence accumulated over the past few years has documented a critical role for adipose tissue (AT)-resident immune cells in the regulation of local and systemic metabolic homeostasis. In the lean state, visceral adipose tissue (VAT) is predominated by anti-inflammatory T-helper 2 (Th2) and regulatory T (Treg) cell subsets. As obesity progresses, the population of Th2 and Treg …

Functions of adipose‐resident immune subsets and the ...

The findings indicate important roles for resident T effector and regulatory cells, innate lymphoid cells (ILCs), invariant natural killer T (iNKT) cells and macrophages, among others in adipose tissue. There is a growing appreciation of the role in the aetiology of metabolic syndrome that is played by the interplay of diet, microbiota and the interactions of immune cells and adipose …