tissue cells feel and respond to the stiffness of their substrate and function

How deeply cells feel: methods for thin gels - IOPscience- tissue cells feel and respond to the stiffness of their substrate and function ,2010-4-26 · Tissue cells lack the ability to see or hear but have evolved mechanisms to feel into their surroundings and sense a collective stiffness. A cell can even sense the effective stiffness of rigid objects that are not in direct cellular contact—like the proverbial princess who feels a pea placed beneath soft mattresses.What types of forces do cells encounter? - MBInfoDischer DE, Janmey P, and Wang Y. Tissue cells feel and respond to the stiffness of their substrate. Science 2005; 310 (5751):1139-43. [PMID: 16293750] Giannone G, and Sheetz MP. Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways. Trends Cell Biol. 2006; 16 (4):213-23. [PMID: 16529933]



D. E. Discher, P. Janmey and Y.-L. Wang, “Tissue Cells ...

Article citations More>>. D. E. Discher, P. Janmey and Y.-L. Wang, “Tissue Cells Feel and Respond to the Stiffness of Their Substrate,” Science, Vol. 310, No ...

Tissue Cells Feel and Respond to the Stiffness of Their ...

Tissue Cells Feel and Respond to the Stiffness of Their Substrate. Discher, Dennis E. ; Janmey, Paul. ; Wang, Yu-li. Abstract. Normal tissue cells are generally not viable when suspended in a fluid and are therefore said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as rigid as glass or softer than a baby's skin.

Tissue Cells Feel and Respond to the Stiffness of Their ...

2020-3-27 · R E V I E W Tissue Cells Feel and Respond to the Stiffness of Their Substrate Dennis E Discher1* Paul Janmey1 Yu-li Wang2 Normal tissue cells are …

Tissue cells feel and respond to the stiffness of their ...

2005-11-1 · Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher School of Engineering and Applied Science and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104-6315, USA.

[PDF] The stiffness of living tissues and its implications ...

2020-2-21 · The stiffness of tissue components — from extracellular matrix and single cells to bulk tissue — is outlined, and how this understanding facilitates the engineering of materials with lifelike properties is discussed. The past 20 years have witnessed ever-growing evidence that the mechanical properties of biological tissues, from nanoscale to macroscale dimensions, are …

(PDF) Supplementary Material - researchgate

Di scher, D. E., Janmey, P. & Wang, Y.-L. Tissue cells feel and respond to the ... and Respond to the Stiffness of Their Substrate. Article. ... potently regulates cell fate and function in vitro ...

Tissue cells feel and respond to the stiffness of their ...

Normal tissue cells are generally not viable when suspended in a fluid and are therefore said to be anchorage dependent. Such cells must adhere to a solid, but a …

Tissue Cells Feel and Respond to the Stiffness of Their ...

2014-3-19 · DOI: 10.1126/science.1116995 Science 310, 1139 (2005); Dennis E. Discher, et al. Their Substrate Tissue Cells Feel and Respond to the Stiffness of

[PDF] The stiffness of living tissues and its implications ...

2020-2-21 · The stiffness of tissue components — from extracellular matrix and single cells to bulk tissue — is outlined, and how this understanding facilitates the engineering of materials with lifelike properties is discussed. The past 20 years have witnessed ever-growing evidence that the mechanical properties of biological tissues, from nanoscale to macroscale dimensions, are …

Riboflavin and collagen: New crosslinking methods to ...

2012-5-1 · Tissue cells feel and respond to the stiffness of their substrate Science (New York, N.Y.) , 310 ( no. 5751 ) ( Nov. 2005 ) , pp. 1139 - 1143 …

tissue cells feel and respond to the stiffness of their ...

Tissue Cells Feel and Respond to the Stiffness of Their ... Tissue Cells Feel and Respond to the Stiffness of Their Substrate. Normal tissue cells are generally not viable when suspended in a fluid and are therefore said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as rigid as glass or softer than a baby's skin.

Biomaterial based modulation of macrophage ... - …

2015-7-1 · Tissue cells feel and respond to the stiffness of their substrate Science , 310 ( 5751 ) ( 2005 ) , pp. 1139 - 1143 CrossRef View Record in Scopus Google Scholar

The stiffness of living tissues and its implications …

2020-2-21 · Discher, D. E., Janmey, P. & Wang, Y. Tissue cells feel and respond to the stiffness of their substrate. Science 310 , 1139–1143 (2005). A seminal work reporting for the first time that ...

Biophysical and Biochemical Cues of Biomaterials Guide ...

2021-3-25 · Tissue cells feel and respond to the stiffness of their substrate. Science 310 1139–1143. 10.1126/science.1116995 [Google Scholar] Du J., Chen X., Liang X., Zhang G., Xu J., He L., et al. (2011). Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity. Proc.

Tissue Cells Feel and Respond to the Stiffness of Their ...

2020-3-27 · R E V I E W Tissue Cells Feel and Respond to the Stiffness of Their Substrate Dennis E Discher1* Paul Janmey1 Yu-li Wang2 Normal tissue cells are …

D. E. Discher, P. Janmey and Y. L. Wang, “Tissue Cells ...

D. E. Discher, P. Janmey and Y. L. Wang, “Tissue Cells Feel and Respond to the Stiffness of Their Substrate,” Science, Vol. 310, No. 5751, 2005, pp. 1139-1143.

Tissue Cells Feel and Respond to the Stiffness of Their ...

2005-11-18 · Fig. 1.Substrate strain and tissue stiffness. (A) Strain distribution computed in a soft matrix beneath a cell.The circular cell has a uniform and sustained contractile prestress from the edge to near the nucleus ().(B) Stress versus strain illustrated for several soft tissues extended by a force (per cross-sectional area).The range of slopes for these soft tissues subjected to a …

Stiffness Sensing by Cells - PubMed

One of the most important, and the focus of this review, is the effect of substrate mechanical properties on cell structure and function. The past decade has produced a nearly exponentially increasing number of mechanobiological studies to define how substrate stiffness alters cell biology using both purified systems and intact tissues.

Biomaterial based modulation of macrophage ... - …

2015-7-1 · Tissue cells feel and respond to the stiffness of their substrate Science , 310 ( 5751 ) ( 2005 ) , pp. 1139 - 1143 CrossRef View Record in Scopus Google Scholar

A novel, visible light-induced, rapidly cross-linkable ...

2014-3-25 · Tissue cells feel and respond to the stiffness of their substrate 14. The physical properties of scaffold influence cell function and tissue …

Stiffness Sensing by Cells | Physiological Reviews

2020-2-20 · Tissue cells feel and respond to the stiffness of their substrate. ... Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. ... The effect of substrate modulus on the growth and function of matrix-embedded endothelial cells. Biomaterials 34: ...

D. E. Discher, P. Janmey and Y. L. Wang, “Tissue Cells ...

D. E. Discher, P. Janmey and Y. L. Wang, “Tissue Cells Feel and Respond to the Stiffness of Their Substrate,” Science, Vol. 310, No. 5751, 2005, pp. 1139-1143.

Tissue cells feel and respond to the stiffness of their ...

2022-2-4 · Tissue cells feel and respond to the stiffness of their substrate. Science ... whose contractile forces are transmitted through transcellular structures. The feedback of local matrix stiffness on cell state likely has important implications for development, differentiation, disease, and regeneration. ... Matsumoto T. Effects of substrate ...

Tissue Cells Feel and Respond to the Stiffness of Their ...

2014-3-19 · DOI: 10.1126/science.1116995 Science 310, 1139 (2005); Dennis E. Discher, et al. Their Substrate Tissue Cells Feel and Respond to the Stiffness of

Interactions of cells with their environment; Engineering ...

2020-12-30 · Discher, Janmey, Wang, ‘Tissue Cells Feel and Respond to the Stiffness of Their Substrate,’ Science 310 1139-1143 (2005)) Supplementary Reading : ‘The Extracellular Matrix,’ pp. 1124-1150, Molecular Biology of the Cell , Lodish et al.

Tissue Cells Feel and Respond to the Stiffness of Their ...

2020-3-27 · R E V I E W Tissue Cells Feel and Respond to the Stiffness of Their Substrate Dennis E Discher1* Paul Janmey1 Yu-li Wang2 Normal tissue cells are …